Wikipedia:Peer review/Immune system/archive1

Immune system

A vandal @ 211.28.241.136 added the Vfd tage for it (see comments) and actually does have good points about quite a bit of factual innacuracy present in the page. It needs a good peer review.--ZayZayEM 12:56, 6 Feb 2005 (UTC)

Refererences perhaps? I see one - is there more than that one, perhaps easier accissible for a layman? Pictures maybe? I think this article has great potential, but I lack the knowledge to help make it great - otherwise I've would have been editing it, not writing this ;) WegianWarrior 07:00, 8 Feb 2005 (UTC)

I may be a bit late here, but the article seems to contain some sweeping (and wrong) statements which should be cut, such as: 'Also, the innate immune system, with the exception of NK cells, is completely ineffective against viral infections.' Grad students, how about working it over? (My knowledge about Immunology as a whole is out of date ;) ) 84.92.241.124 15:24, 28 September 2006 (UTC)(denni_schnapp@yahoo.co.uk)

Immune system

This page is totally misguided, wrong, and out of date. Most of the information is incorrect. Please read a good immunology reference text to correct it.

Peer review

Following the annoying VFD notice, I do think this page needs major overhaul. There is a lot of material with very little structure.

Some points:

• Start with a clear outline:
  • forms of immunity, e.g. specific vs. nonspecific)
  • organs involved
  • cell types involved
  • physiology (forms of immune reaction, e.g. anaphylactoid vs delayed-type, Th1 vs Th2)
  • pathology (autoimmunity, immune deficiency)
  • analysis of immune function
  • medical modulation of immune response (e.g. vaccination, immune suppression, cytokines)
• This outline can then be filled from a few reliable sources that are readily accessible to the average library visitor or internet user. Let's please avoid 400 references for all sorts of fringe POVs.
• We will get punished for making errors, not for leaving out tiny details. This article is only an overview, with pointers to subarticles of relevance.

Which authors would like to help? I'd love to, but my main contributions will probably not come until after April. JFW | T@lk 22:07, 6 Feb 2005 (UTC)

I quickly glanced at the article and it does need some updating, which I plan to do. Some claims by the author of the VfD are wrong:

• B cells are named for bone marrow, as opposed to T cells that come from and proliferate in the thymus.

  Incorrect. The "B" originally stood for bursa of Fabricius, an organ in birds in which B cells mature. T cells do NOT "come from" the thymus -- they undergo development in the thymus, but, like all cells in the blood, they come from hematopoetic stem cells in the bone marrow. jdb ❋ 23:16, 8 Feb 2005 (UTC)

• Description of neutrophil is correct
• Innate section is lacking current information, but acquired seems correct

I think much of the information was taken from an older textbook or something, but it's not intentionally wrong or an embarassment. --jag123 16:00, 8 Feb 2005 (UTC)

• I disagree. As hysterical as the VfDer was, the article was in pretty bad shape. He certainly prompted me to make some changes. jdb ❋ 23:16, 8 Feb 2005 (UTC)

After actually reading the article, I have to agree with you jdb; it is in bad shape. Regarding B cells, I've seen many references to B standing for "bone marrow" and never (up until now) to bursa of fabricius. Do you have a reference as to who coined the term? I'm not arguing that it's false, but since the bone marrow "origin" is so commonly used, it'd be nice to settle this misconception. By the way, T cells do come from the thymus. A few migrate from the bone marrow into the thymus and proliferate, so that means that all of the T cells circulating in the blood actually come from the thymus. That's like saying osteoblasts don't come from the periosteum because their distant ancestors originated from marrow stromal cells. Don't be so pedantic. --jag123 12:15, 9 Feb 2005 (UTC)

The answer to the question "what the B of B lymphocyte stands for?" is the following: The B term originally stood for bursa of Fabricius of the birds as correctly mentioned in a previous post. However since there's no such organ in mammals and these cells in mammals mature in the bone marrow it is not incorrect to say that in mammals the B stands for bone marrow.—Preceding unsigned comment added by 213.199.15.66 (talk • contribs) 2006-05-19t14:30:08z